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2014 Spinal Cord Injury Wellness Summit

 

The Use of Medical Marijuana to Manage Symptom Burden in Spinal Cord Injury

 

By Gregory T. Carter, MD, MS

Medical Director, St. Luke's Rehabilitation Institute, Spokane, Washington, and faculty, University of Washington Medical School

The national conversation about cannabis (marijuana) is changing rapidly, and many people with SCI would like to know more about its use as a medical treatment for pain and other symptoms. In this forum presentation, Dr. Carter discusses the history of medical cannabis in the U.S., the physiological effects of cannabis, and the current scientific evidence regarding the safety and effectiveness of cannabis as a treatment for neuropathic pain when used under a physician's supervision. Watch the video or read the report, below.

Download the presentation slides (PDF)

 

Presentation time: 54 minutes. After watching, please complete our two-minute survey!

You can also watch this video on YouTube with or without closed-captioning. For a complete list of our SCI Forum videos, go to http://sci.washington.edu/info/forums/forum_videos.asp.

Report

Contents

Introduction

Marijuana (cannabis) is much in the news today. Medical marijuana, although still illegal under federal law, has been legal in several states for some time, and state laws about recreational marijuana are changing. As marijuana becomes more available, people interested in medical marijuana want information about what it is, what it’s good for, and how to use it.

What is Marijuana (Cannabis)?

Marijuana refers to the dried leaves, flowers, stems and seeds from the hemp plant Cannabis sativa, which contains numerous active chemical compounds called cannabinoids. Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive ingredient in cannabis that acts on the brain and changes mood or consciousness. Other chemical compounds in cannabis that have biologic activity include cannabinol (CBN), cannabidiol (CBD), and cannabichromene. CBD, in particular, is thought to have significant analgesic (pain-relieving) and anti-inflammatory activity without the psychoactive effect (high) of THC.

History and Background

Cannabis has been used for medicinal purposes for thousands of years. It was first brought into western medicine in the 1840s by an English surgeon who learned about it in his travels through the Middle East. 

For several decades cannabis was regularly prescribed by physicians in the U.S. and dispensed at pharmacies as a tincture or tonic for “nerve pain.” Beginning in 1937 the federal government started taxing and restricting its use, in spite of objections by the American Medical Association. In 1951 cannabis was classified as a narcotic, and finally in 1970 it was classified as a schedule 1 drug (like heroin and LSD), meaning it is considered dangerous and without accepted medicinal use. It has remained in this classification despite favorable findings from various government-appointed commissions on cannabis over the years: Nixon-appointed Shafer Commission in 1972; U.S. Institute of Medicine in 1982; and the U.S. National Institutes of Health Workshop on Medical Marijuana in 1997. Furthermore, the National Academy of Sciences and the American College of Physicians have all issued cautiously positive statements about cannabis.

“I’m here to say on the record that the classification as a schedule 1 drug doesn’t make any sense scientifically,” Carter said.

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How Does it Work?

“We now understand a great deal about how cannabis works in the body,” Carter said. The cannabinoids activate specific receptors found throughout the body to produce pharmacologic effects, particularly in the central nervous system and the immune system. Pain is reduced when cannabis receptors are activated in the nervous system pathways that regulate pain perception.

When it is smoked, cannabis compounds pass rapidly from the lungs to the bloodstream, which carries the chemical to the brain and other organs. Vaporized cannabis produces the same effects without the smoke. It is absorbed more slowly when ingested in food or drink. The highest density of cannabinoid receptors is found in parts of the brain that influence pleasure, memory, thinking, concentration, sensory and time perception, and coordinated movement.

“I first stumbled onto medical cannabis 20 years ago when an ALS patient told me she was using it for pain and spasticity,” Carter recalled. “When medical marijuana became legal in Washington State, I began prescribing it.”

Medical vs Recreational Cannabis

Recreational strains are much different than the medical strains,” Carter said.  Recreational marijuana has high levels of the THC compound because of its mind-altering effects, and that’s what recreational users are looking for. Medical cannabis is low in THC and higher in other compounds that help with pain and spasticity, such as cannabidiol (CBD) and cannabinol (CBN).

“Many people taking medical cannabis do not want to get high, and some find the intoxication unpleasant,” Carter said. “My ALS patients take cannabis to ease their suffering so they can spend quality time with their families. They don’t want to be intoxicated; they want to be present.”  

Research

Because cannabis is a schedule 1 drug, it has been difficult to get funding to conduct research on its medical use. In spite of this hurdle, “we now know on the basis of science and clinical trials that cannabis and cannabinoids work very well for neuropathic pain and spasticity,” Carter said. 

Several studies involving people with a variety of diagnoses have had promising results.1-3 A 2011 systematic review of 18 randomized clinical trials of cannabinoids for non-cancer pain found significant analgesic effects with no serious adverse effects.4

“The overall weight of evidence so far is markedly in favor of cannabinoids being safe and effective to treat pain,” Carter concluded.

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Benefits of Medical Cannabis 

Using Medical Marijuana

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A Word of Caution

Carter points out that “cannabis is not for everybody. It has side effects.” Cannabis can cause disinhibition, relaxation, drowsiness, feeling of well-being, exhilaration and euphoria. It can also cause disorganized thoughts, confusion, agitation and paranoia. Since it can impair your balance and stability, individuals who are able to walk need to be careful to avoid falling. Finally, it impairs memory, judgment and motor skills, so don’t drive!

Take-Home Message

Resources

References

  1. Abrams DI, Rowbotham MC, Petersen KL, et al. Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial. Neurology 2007; 68(7):515-21.
  2. Rog DJ, Nurmikko TJ, Friede T, Young CA. Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis. Neurology 2005; 65(6):812-9.
  3. Johnson et al. 2009. Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety and tolerability of THC: CBD extract in patients with intractable cancer-related pain. Journal of Symptom Management 39: 167-179.
  4. Lynch ME, Campbell F. Cannabinoids for Treatment of Chronic Non-Cancer Pain; a Systematic Review of Randomized Trials. Br J Clin Pharmacol 2011 2(5):735-44.

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