Past Research Projects
Funded through the NIDRR SCI Model Systems Program

2006-2011 Funding Cycle:

• “SCI-Link”(Linking people with SCI to health resources)
  Many people with SCI tell us that the first year after discharge from rehabilitation is very difficult because they have so many questions and new problems to solve but don’t always know where to find the information they need. To address this, we designed a study to determine whether providing regularly scheduled telephone follow-up calls to people with SCI after discharge can help them get the care they need, solve problems that arise, and avoid the medical complications that people often experience during their first year after SCI. Jeanne Hoffman, PhD, was the principal investigator for this study. Findings from the study, completed in 2011, will be published and posted here.
  
  
• The effects of venlafaxine XR (Effexor XR) after SCI – "PRISMS" (Project to Improve Symptoms and Mood after SCI). One out of five people with SCI report problems with sleep, poor energy, low mood, loss of interest and appetite changes. These symptoms may result in part from stress-related changes in brain chemistry. Antidepressant medications such as venlafaxine XR (Effexor XR) are designed to rebalance brain chemistry and improve these basic biological functions. Despite widespread use of antidepressants, they have never been proven to be effective in people with SCI. We studied the effects of venlafaxine XR on these symptoms and on pain in people who were at least one year post-SCI. Participants were randomized to receive a 12-week course of either venlafaxine XR or a placebo. Those who received placebo and remained symptomatic at the end of the trial are offered free treatment with venlafaxine XR. The study is now closed. Findings will be published and posted here.
  
  
• Multi-site study – “Adapt”
  There are many myths about adaptation to SCI, such as the belief everyone must go through a grief process or everyone gets depressed. We hope to improve how we assist people with SCI by gathering information on what people experience after SCI, what treatments they receive and how they view their own health physically and emotionally over time. This study follows people from inpatient rehabilitation to one year after injury. Chuck Bombardier, PhD, is the principal investigator for this study. Findings from the study will be published soon and posted here.

2000-2005 Funding Cycle:

• “The prevalence and implications of sleep apnea in acute, traumatic tetraplegia” was led by Dr. Stephen Burns, assistant professor in Rehabilitation Medicine. Sleep apnea is more common among persons with SCI than in the general population and can have serious, harmful effects on health, function, and quality of life. Yet sleep apnea is little recognized or understood among physicians, even those who regularly treat SCI patients. The goal of this study was to better understand the frequency of sleep apnea in the acute SCI population and its effect on rehabilitation. Read more...

• "Hydrophilic catheters for prevention of UTIs: A randomized clinical trial in chronic SCI," led by Diana Cardenas, MD, investigated a new type of catheter designed to reduce urinary tract infections (UTIs) by minimizing the opportunity for bacteria to enter the bladder system. Read more...

• Collaborative Upper Limb Pain (CULP-SCI). This was a three-site collaborative study centered at the University of Pittsburgh. This study examined the manual wheelchair propulsion and transfer techniques used by people with SCI that over time can contribute to the high incidence of disabling upper limb pain in this population. The Seattle arm of the study was directed by Dr. Michael Chang, associate professor in the Department of Rehabilitation Medicine. In the UW's state-of-the-art Human Motion Analysis Laboratory, subjects underwent initial biomechanical studies that measured the mechanics of their wheelchair techniques. Following that, subjects participated in periodic telephone interviews that monitored upper limb pain and disability over a five year period. Data collection is complete but analyses continue and results are being published. See the list of publications from this study.
  
  
• Clinical Outcomes of Spinal Cord Injury: A retrospective review
  Directed by Sohail Mirza, MD, associate professor in the Department of Orthopedic Surgery, this study is examining spinal cord injury cases that occurred between 2003 and 2005 to determine whether earlier spine surgery results in better outcomes than later surgery, how much improvement occurs with earlier intervention, and what is the complication rate. This study hopes to shed light on the controversy over whether it is preferable to perform surgery very soon after injury, before further damage occurs, or later, after the patient has stabilized and risks from surgery have declined.